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Vice President Joe Biden is fresh out of the Obama White House and feeling adrift when his favorite railroad conductor dies in a suspicious accident, leaving behind an ailing wife and a trail of clues. To unravel the mystery, "Amtrak Joe" re-teams with the only man he's ever fully trusted: the 44th president of the United States. Together they'll plumb the darkest corners of Delaware, traveling from cheap motels to biker bars and beyond, as they uncover the sinister forces advancing America's opioid epidemic.