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Understanding the many complex cellular and molecular mechanisms underlying human vascular diseases is essential in improving the treatment of this important and wide-ranging group of diseases that affect a large proportion of the world po- lation. This book is based on lectures presented at an International Vascular Biology Workshop held in London and chaired by Professor Dame Carol Black. The c- tents are complemented by some invited chapters, all written by world experts in areas of basic science and clinical medicine highly relevant to vascular biology and disease. We are particularly grateful to Professor Arshed Quyyumi, Professor of Medicine and Cardiology at Emory University, who with his research group and clinical colleagues, has provided a substantial contribution to this book. In common with our previous book - Vascular Complications in Human Disease: Mechanisms and Consequences published by Springer in 2008, our aim with this book is to highlight some of the established relationships between basic science and clinical medicine, and to outline new and exciting fields of research and practice in vascular biology and pathobiology. There are two sections: Basic Science of Vascular Biology and Clinical Aspects of Vascular Biology. In the first section, dealing with basic science, we have included three important growth areas: "Genetics and Gene Therapy" cover approaches to gene therapy and delivery systems, "Animal Models to Study Vascular Disease" with chapters on animal models of scleroderma, animal models of atherosclerosis, and finally on the endothelin system.

Understanding the many complex cellular and molecular mechanisms underlying human vascular diseases is essential in improving the management of patients with this clinically important and wide-ranging group of diseases. This is particularly important when considering the extent of this issue across the world. Written by a team of world-renowned authorities, Advances in Vascular Medicine highlights some of the relationships between basic science and clinical medicine, and reviews both research and clinical practice methods and outcomes in vascular biology and pathobiology. It is an authoritative reference for these important topics of vascular biology and includes chapters that explain the clinical issues to the basic scientist as well as providing clinicians with a scientific grounding in vascular diseases. Although there is still much work to be done to advance understanding of vascular disease, the information and insights contained in this book are a vital contribution to the literature, giving scientists and clinicians the opportunity to learn more about this exciting field of biomedicine.