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The present study aimed to evaluate the possible therapeutic role of bone marrow mesenchymal stem cells (BM-MSCs) and adipose tissue derived mesenchymal stem cells (ASCs) in management of osteoporosis in ovariectomized females rats. Our results clearly demonstrated the effective role of MSCs in management of osteoporosis via their ability to generate osteoprogenitors and to differentiate into osteoblasts as well as their anti-inflammatory properties. Noteworthy, the combination of MSCs with an osteoinductive material may be useful to achieve more pronounced therapeutic effect