Detailansicht

The ability of a single genome to give rise to hundreds of functionally distinct cell type programs is in itself remarkable. Pioneering studies over the past few decades have demonstrated that this plasticity is retained throughout development, a phenomenon of epigenetic programming and reprogramming that remains one of the most fascinating areas of modern biology, with major relevance to human health and disease. This book presents the basic biology involved, including key mechanistic insights into this rapidly growing field.

InhaltsangabePreface Part I  Germ cell and early embryo (epigenetic) programs: Histone variants early reprogramming Control of germ line development and reprogramming DNAmethylation dynamics in early mouse embryos The oocyte determinants of early reprogramming The sperm epigenome and early development CpG island methylation in oocytes and early embryos Stella and zygotic reprogramming   Part II  Direct reprogramming of somatic cells and iPS reprogramming Small RNAs and reprogramming Epigenomes of iPS cells Pathways for direct reprogramming   Part II  Epigenetic control of ES cells Role of pluripotency factors in X-chromosome silencing Modulation of epigenetic cell states in ES cells TDG and control of epigenetic identity in ESCs The role of novel DNA-modifications in stem cells  Epigenomics of stem cell programmes                                     Part IV  Epigenetic control of somatic stem cell identity Epigenetic maintenance of pluripotency by polycomb group proteins Function of Mi-NuRD in B cell programming Epigenetic reprogramming in cancer   Glossary Index