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This book constitutes the proceedings of the 32nd International Workshop on Combinatorial Algorithms which was planned to take place in Ottawa, ON, Canada, in July 2021. Due to the COVID-19 pandemic the conference changed to a virtual format.The 38 full papers included in this book together with 2 invited talks were carefully reviewed and selected from 107 submissions. They focus on algorithms design for the myriad of combinatorial problems that underlie computer applications in science, engineering and business.Chapter "Minimum Eccentricity Shortest Path Problem with Respect to Structural Parameters" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.