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Drug Evaluation in Angina Pectoris

Developments in Cardiovascular Medicine 158
ISBN/EAN: 9780792328971
Umbreit-Nr.: 1439995

Sprache: Englisch
Umfang: xvi, 262 S.
Format in cm:
Einband: gebundenes Buch

Erschienen am 30.11.1994
€ 160,49
(inklusive MwSt.)
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  • Zusatztext
    • InhaltsangabePart I: Pathophysiology, Clinical Presentation and Prognosis of Angina Pectoris; G. Specchia, S. Ghio. Part II: Evaluation of the Patient with Angina Pectoris. 1. Clinical value of anginal symptoms and their assessment in drug trials; S. Savonitto, P.A. Merlini. 2. Quality of life assessments in clinical trials of angina pectoris; I. Wilund. 3. Optimizing the exercise test for pharmacologic studies in patients with angina pectoris; J. Myers, V.F. Froelicher. 4. Evaluation of transient myocardial ischemia by Holter monitoring; A.A. Quyyumi. 5. Radionuclide methods for the evaluation of ventricular function and thrombolytic therapy; P. Marzullo, A. Gimelli, A. L'Abbate. 6. Provocative testing of coronary vasoconstriction; M. Previtali, P. Barberis, D. Ardissino. 7. Pharmacological investigations with invasive methods; E. Bramucci. Part III: Planning, Conducting and Evaluating Clinical Trials in Angina Pectoris. 1. Patient selection and definition of study endpoints; P. Schulman, D. Waters. 2. Controlling potential sources of bias in clinical trials of antianginal agents; M. Motolese. 3. Parallel group and crossover designs for drug evaluations in the various forms of angina pectoris; S. Savonitto. 4. Dose response relationships and combination studies with antianginal agents; U. Thadani. 5. Sample size and power of clinical trials; E. Eleuteri, D. Ardissino. 6. Multicenter trials: design and conduct; A. McNeill, J. Lubsen. Part IV: Critical Issues related toSpecific Antianginal Agents. 1. Experimental evaluation and the clinical relevance of tolerance to nitrates; J.O. Parker, J.D. Parker. 2. Clinical evaluation of betablockers in the various forms of angina pectoris; N. Rehnqvist. 3. Efficacy and safety of calcium antagonists as antianginal agents; L.H. Opie. 4. Effects of antithrombotic agents on mortality and nonfatal cardiac events; P. Theroux, R.M. Lidon. 5. The challenge of thrombolytic therapy in unstable angina pectoris; J.A. Venditto, J.A. Ambrose. Part V: Regulatory Aspects related to the Evaluation of New Antianginal Agents. 1. Comments on the Food and Drug Administration (FDA) Advisory Panel Recommended Guidelines for the Conduct of Antianginal Drug Trials; U. Thadani. 2. EEC Guidelines for the evaluation of antianginal agents; B. Dupuis. Index.

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