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The motivation for us to conceive this work on regulation was mainly our belief that it would be fun, and at the same time productive, to approach the subject in a way that differs from that of other treatises. We thought it might be interesting and instructive-for both author and reader-to examine a particular area of investigation in a framework of many different problems. Cutting across the traditional boundaries that have separated the sub jects in past volumes on regulation is not an easy thing to do-not because it is difficult to think of what interesting topics should replace the old ones, but because it is difficult to find authors who are willing to write about areas outside those pursued in their own laborato ries. Anyone who takes on the task of reviewing a broad area of interest must weave together its various parts by picking up the threads from many different laboratories, and attempt to produce a fabric with a meaningful design. Finding persons who are likely to succeed in such tasks was the most difficult part of our job. In the first volume of this treatise, most of the chapters dealt with the mechanisms of regulation of gene expression in microorganisms. This second volume involves a somewhat broader area, spanning the prokaryotic-eukaryotic border.

Inhaltsangabe1 Regulation of Enzyme Activity.- 2 Protein Folding: Evolutionary, Structural, and Chemical Aspects.- 3 Regulation of Structural Protein Interactions as Revealed in Phage Morphogenesis.- 4 Mechanisms Regulating Pattern Formation in the Amphibian Egg and Early Embryo.- 5 Biochemistry and Regulation of Nonmuscle Actins: Toward an Understanding of Cell Motility and Shape Determination.- 6 The Regulation of Cell Behavior by Cell Adhesion.- 7 Sensing the Environment: Bacterial Chemotaxis.- 8 Regulation of Membrane Transport.- 9 Immunoglobulin Diversity: Regulation of Expression of Immunoglobulin Genes during Primary Development of B Cells.- 10 Immune Response Genes in the Regulation of Mammalian Immunity.