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InhaltsangabeContributors, vii Foreword, x Preface, xii Steve Kitchen, John D. Olson, & F. Eric Preston Part 1: General Quality Program 1 General quality planning in the hemostasis laboratory, 3 John D. Olson 2 Hemostasis test validation, performance, and reference intervals: international recommendations and guidelines, 12 Richard A. Marlar 3 Causes of errors in medical laboratories, 22 Giuseppe Lippi & Emmanuel J. Favaloro 4 International standards in hemostasis, 32 Trevor W. Barrowcliffe & Anthony R. Hubbard 5 Sample integrity and preanalytical variables, 45 Dorothy (Adcock) Funk 6 Internal quality control in the hemostasis laboratory, 57 Steve Kitchen, F. Eric Preston, & John D. Olson 7 External quality assessment in hemostasis: its importance and significance, 65 F. Eric Preston, Steve Kitchen, & Alok Srivastava 8 The unique challenges of hemostatic testing in children, 77 M. Patricia Massicotte, Mary E. Bauman, Vanessa Chan, & Anthony K.C. Chan Part 2: Quality in Coagulation Testing 9 Initial evaluation of hemostasis: reagent and method selection, 95 Wayne L. Chandler 10 Assay of factor VIII and other clotting factors, 105 Steve Kitchen & F. Eric Preston 11 Application of molecular genetics to the investigation of inherited bleeding disorders, 115 Stefan Lethagen, Morten Dunø, & Lars Bo Nielsen 12 Detecting and quantifying acquired functional inhibitors in hemostasis, 124 Bert Verbruggen, Myriam Dardikh, & Britta Laros-van Gorkom 13 Standardization of d-dimer testing, 136 Guido Reber & Philippe de Moerloose 14 Pointofcare testing in hemostasis, 147 Chris Gardiner, Dianne Kitchen, Samuel Machin, & Ian Mackie Part 3: Quality in Testing for Platelet Function and von Willebrand Disease 15 Diagnostic assessment of platelet function, 159 Paquita Nurden, Alan Nurden, & Martine Jandrot-Perrus 16 Laboratory evaluation of heparin-induced thrombocytopenia, 174 Theodore (Ted) E. Warkentin & Jane C. Moore 17 Laboratory evaluation of von Willebrand disease: phenotypic analysis, 192 Emmanuel J. Favaloro 18 Laboratory analysis of von Willebrand disease: molecular analysis, 204 Anne C. Goodeve & Ian R. Peake Part 4: Quality in Thrombophilia Testing and Monitoring Anticoagulation 19 Quality issues in heritable thrombophilia testing, 219 Isobel D. Walker & Ian Jennings 20 Evaluation of antiphospholipid antibodies, 233 Michael Greaves 21 Monitoring heparin therapy, 244 Marilyn Johnston 22 Monitoring oral anticoagulant therapy with vitamin K antagonists, 253 Armando Tripodi 23 Monitoring new anticoagulants, 264 Elaine Gray & Trevor W. Barrowcliffe Index, 273