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InhaltsangabeSection I: Localized Disease1.      Etiology of RCC: Incidence, Demographics, and Environmental FactorsBy Frédéric D. Birkhäuser, MD, Nils Kroeger, MD, and Allan J. Pantuck, MD MS FACS 2.      Pathology of Renal Cell CarcinomaBy Ming Zhou, MD PhD, Huiying He 3.      Familial Renal Cell CarinomaBy Simon P. Kim, MD, MPH,  Bradley C. Leibovich, MD 4.      Imaging of Renal Cell Carcinoma By Andrei S. Purysko, MD, Erick M. Remer MD, Brian R. Herts, MD 5.      Prognostic Factors for Localized Renal Cell Carcinoma By Brian R. Lane, MD, PhD. Section II: Management of  Localized RCC 6.      Assessment of Oncologic Risk for Clinical Stage T1 Renal Tumors and the Emerging Role of Renal Mass BiopsyBy Matthew N. Simmons MD PhD,  Steven C. Campbell MD PhD 7.      Radical Nephrectomy for Localized Renal Tumors: Oncological and Renal Functional ConsiderationsBy Paul Russo, MD FACS 8.      Nephron-Sparing Surgery for Renal Cancer By Alon Z. Weizer MD, MS, Jeffery S. Montgomery MD, MHSA, Khaled S. Hafez, MD 9.      Thermal AblationBy Surena F. Matin MD FACS, Kamran Ahrar MD 10.  Active Surveillance of the Small Renal MassBy Marc C. Smaldone, MD, Daniel Canter,  MD, Alexander Kutikov, MD,  Robert G. Uzzo, MD FACS Section III: Locally Advanced Disease 11.  Locally Advanced Renal Cell CarcinomaBy Stephen H. Culp, MD PhD, Christopher G. Wood, MD FACS 12.  Neoadjuvant Targeted Therapy and Consolidative Surgery By Sean P. Stroup MD. Ithaar H. Derweesh, MD Section IV: Advanced Disease 13.  Biology of RCC (VEGF, mTOR, immune aspects) By Alexandra Arreola, W. Kimryn Rathmell, MD, PhD 14.  Prognostic Factors in Advanced Renal Cell Carcinoma  By Michael M. Vickers MD, Daniel Y. C. Heng MD MPH 15.  Integration of Surgery in Metastatic Renal CancerBy Tom Powles, MBBS MRCP MD,  Axel Bex, MD 16.  Immunotherapy for Renal Cell CarcinomaBy Diwakar Davar, MD,  Moon Fenton, MD, Leonard J Appleman, MD, PhD 17.  Targeted Therapy: Vascular Endothelial Growth Factor (VEGF)  By Linda Cerbone MD, Cora N. Sternberg, MD 18.  mTOR in Renal cell carcinomaBy Eric Jonasch, MD, Michel Choueiri, MD 19.  Palliative and Supportive Care for Renal Cancer By Armida Parala-Metz MD, Mellar Davis MD

Renal Cell Carcinoma: Clinical Management provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in kidney cancer. The volume reviews new data about risk factors for the disease, profiles the new staging system for renal cell carcinoma (RCC), highlights our current understanding of familial syndromes of RCC and their molecular genetics, and provides new perspectives about imaging of renal tumors. For localized disease, a greater appreciation of nephron-sparing approaches and the importance of preservation of renal function is discussed in detail. Advances in surgical techniques are highlighted. For metastatic disease, the molecular biology of kidney cancer is reviewed in a concise and understandable manner, including the data that has fostered novel targeted approaches that have revolutionized management. The several landmark phase III targeted therapy trials published in the last few years are placed in context with respect to current management.