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The RISE (Rare Disease) Selling Framework is meant to be disruptive! It is designed to help commercial teams identify how to inspirationally RISE and become a rare voice for rare disease patients. It is challenging oneself and not the healthcare professional. In keeping aligned with biopharmaceutical organizations' respective mission statements, industry's customer interfacing teams must always keep patients top of mind. It is an important journey, a journey of putting patients first by challenging oneself to reach beyond and become a cogent rare voice for rare disease patients. The RISE Selling Framework is a transformational approach that focuses on Inspiration. It is about mustering the daily will and skill to reach beyond, because it is the patients who are fighting every day to reach beyond. They are creating Inspirational steps that lead to Inspirational stories. We must RISE every-single-day because our healthcare professionals RISE every-single-day and our patients RISE every-single-day to fight, touch others, and share their gifts. RISE, it's a new day. Are you ready to reach beyond your current skill set for rare disease patients?