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InhaltsangabeA. Cellular and Metabolic Changes Cause by Mineral Dusts.- 1. The Role of Active Oxygen Species in Uptake of Mineral Particles by Tracheobronchial Epithelial Cells.- 2. Oxygen Radical Generation by Asbestos and Its Correlation to Cytotoxicity.- 3. Fiber-Induced Hydroxyl Radical Formation and DNA Damage.- 4. Involvement of the Oxidative Stress in the Toxicity of Iron-Containing Particles on Tracheal Epithelium in Primary Culture.- 5. The Role of Iron in Asbestos-Induced Cancer.- 6. Time-lapse Video Light Microscopic and Electron Microscopic Observations of Vertebrate Epithelial Cells Exposed to Crocidolite Asbestos.- 7. The Effect of MMMF on the Kinetics of Cytokine Expression in Murine Lung Populations: Role in Fibre-induced Disease.- 8. The Second Messenger System in Diseases Caused by Mineral Dusts.- 9. Transcriptional Regulation of IL-1ß and IL-6 by TNF-? in Asbestosis Is Mediated by NF-IL6-like Motifs.- 10. Type II Epithelial Cell Proliferation and Surfactant Lipid Turnover in Silicosis.- 11. Role of Nitric Oxide Radicals in Asbestos-Induced Injury.- 12. Cytotoxicity and Cell-stimulating Activity of Ultrafine Titanium Dioxide.- 13. Carcinogenic Effects in Rats of Exposure to Different Minerals from Metallic Mine Ores, Radon and Radon Daughters.- 14. Biological Effects of a New Type of Pure Carbon (Fullerenes) in vitro.- B. Molecular Changes and DNA Alterations Produced By Mineral Dusts.- 1. Augmentation in the Differential Oxidative DNA-Damage by Asbestos in Presence of H2O2 and Organic Peroxide/Hydroperoxide.- 2. In vitro, DNA and Chromosome Damage Produced by Some Minerals and Man-Made Particles on Rat Pleural Mesothelial Cells (RPMC) - Mechanisms and Relationship with in vivo Experimental Findings.- 3. Evaluation of Proinflammatory Cytokine Expression in Alveolar Macrophages and in the Lung of Pneumoconiotic Patients.- 4. Activation of Early Cellular Responses by Asbestos: Induction of c-FOS and c-JUN Protooncogene Expression in Rat Pleural Mesothelial Cells.- 5. Molecular Alterations in Murine Mesotheliomas Induced by Crocidolite Asbestos.- 6. Long and Short Amosite Asbestos Samples: Comparison of Chromosome-damaging Effects to Cells in Culture with in vivo Pathogenicity.- 7. Induction of DNA Damage after Rats Exposure to Crocidolite Asbestos Fibres.- 8. Unscheduled DNA Synthesis (UDS) Induced in vitro by Cadmium in Tracheal Epithelial Cells of Rat and Hamster.- C. In Vivo Dust-Related Pathological Processes: Correlations Between In Vitro And In Vivo Data.- 1. Pulmonary Toxicity of Cobalt-containing Dusts.- 2. Chronic Inhalation Toxicity of Fibrous Glass in Rats.- 3. A Comparison of Alveolar Macrophage Cytotoxicity and Ability to Cause Inflammation in the Mouse Peritoneal Cavity for a Range of Different Fibre Types at Equal Fibre Number.- 4. Correlation of in vitro and in vivo Studies on the Bioeffects of Mineral Particles.- 5. Comparative Studies with Natural and Man-Made Mineral Fibres in vitro and in vivo.- 6. Comparison of Pulmonary Effects in Rats Exposed to Size-Separated Preparations of Para-Aramid or Chrysotile Asbestos Fibres after 2-week Inhalation Exposures.- 7. Investigation of the Biodurability and Carcinogenicity of Different Man-Made Mineral Fibres.- 8. Quantitative Relationship Between Emphysema and Lung Minerals in Man.- 9. Carcinogenic Asbestos Fibers in the Parietal Pleura.- 10. Pleural Lesions Induced by Mineral Dusts, Fibers and Chemicals.- 11. Comparisons of in vitro Cytotoxicity Results with in vivo Pulmonary Effects Following Inhalation Exposures to a Variety of Mineral Dusts: How Well Do They Compare?.- D. Physico-Chemical Properties Of Minerals in Relation yo Their Biological Effects.- 1. Particle-Associated Hydrocarbons and Lung Cancer; the Correlation Between Cellular Dosimetry and Tumour Distribution.- 2. Which Surface Functionalities Are Implied in Dust Toxicity.- 3. Role of Transition Metal Compounds in the Capacity of Dusts to Generate Electrophilic Species.- 4. Surface Properties of Res

Proceedings of the NATO Advanced Study Institute on Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres, held in Paris, France, October 11 - 13, 1993