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The aim of the current work to determine the association of the immunological and genetic factors in the risk of unexplained recurrent pregnancy miscarriage in Iraqi women population, specially to investigate the relationship between recurrent spontaneous miscarriage (RSM) and polymorphisms of cytokine genes coding for Interleukin-2 (IL-2) (-330 AC) and Tumor necrosis factor-alpha TNF- (-308 GA) as T helper-1 or pro-inflammatory factors as well as Interleukin IL -10 (-1082 AG) as T helper-2 cytokines in women with RSM compared with healthy women, and analyze the blood serum levels of these cytokine, where the prevalence of three known promoter polymorphisms in Iraqi women with RSM will be determined and compared to healthy controls Specific objectives 1. To calculate the percentage for etiology factors in women patients with recurrent spontaneous miscarriage and enrolled the unknown cases. 2. To measure mean serum level of interleukin (IL-2, TNF-, IL-10) for women with recurrent spontaneous miscarriage and compare it with that in the control group. 3. To investigate genotype and allele frequencies of TNF- (-308 GA), IL-2 (330 AC), and IL-10 (-1082 A/G), IL-2_-330 A/T) and TNF- (-308 g/a) and RSM in Iraqi women.