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Cucurbits including bottle gourd, sponge gourd, bitter gourd, pumpkin and cucumber are important vegetables around the world. Different viral diseases adversely affect cucurbit production. Cucumber green mottle mosaic virus (CGMMV) is an important seed transmitted virus of cucurbits. CGMMV was widespread in cucurbit crops of the studied regions of Pakistan. Coat protein gene of the detected isolate from Pakistan (CGMMV-Pak) had a very high similarity with isolates from other regions of the world. Amino acid sequence was highly conserved. No diversity was observed in coat protein gene sequence of CGMMV-Pak with the other sequences based on phylogenetic relationship. Certain dry heat and chemical treatments of infected bottle gourd seeds were found effective in inactivating virus particles and checked seed transmission of CGMMV. Findings presented in this book will be useful to students, scientists and cucurbit producers in many regions of the world.